Intratumoral and peritumoral lymphatics - New Insights

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Intratumoral and peritumoral lymphatics - New Insights

Postby patoco » Thu Jan 04, 2007 12:08 am

Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics.

Cancer Metastasis Rev. 2006 Dec 12;

Ji RC.
Department of Anatomy, Biology and Medicine, Oita University Faculty of
Medicine, Oita, 879-5593, Japan,

Lymphatic metastasis of tumor cells represents a series of extremely
complex and sequential processes that include dissemination and
invasion into surrounding stromal tissues from primary tumors,
penetration into lymphatic walls and implantation in regional lymph
nodes, and extravasation or proliferation in parenchyma of target
organs. Recent developments in lymphatic biology and research,
especially the application of unique molecular markers specific for
lymphatic endothelial cells (LECs), LYVE-1, Prox-1 and podoplanin have
provided exciting new insights into the tumor microenvironment and
LEC-tumor cell interface. To date, established factors for determining
the behavior and prognosis of primary tumors have been emphasized
morphologically and physiologically, i.e., lymphatic impairment and
vessel density, dysfunction of lymphatic valves, interstitial fluid
pressure, as well as a series of lymphangiogenic growth factors
including VEGF-C/-D, and other cytokines and chemokines. Increasing
knowledge of the tumor biological significance in lymphatics within the
tumors (intratumoral lymphatics, ITLs) and at the tumor periphery
(peritumoral lymphatics, PTLs) has greatly promoted understanding of
tumor access into the lymphatic system by inducing lymphangiogenesis or
by co-opting preexisting lymphatics. Therefore, the targeting PTLs and
ITLs, which have been proposed as an important route for antimetastatic
approach, are deemed worthy of further study in various animal tumor
models and human tumors.

PMID: 17160713 [PubMed - as supplied by publisher] ... etrieve&...


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